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KMID : 0359020070350050313
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Korean Journal of Gastrointestinal Endoscopy
2007 Volume.35 No. 5 p.313 ~ p.320
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Expression of TGF-?1, TGF-? Receptor Type II and VEGF in Colorectal Adenomas and Adenocarcinomas
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Kang Sang-Bum
Han Sok-Won
Choi Gyu-Yong
Lee Seung-Woo
Kim Yon-Soo
Nam Soon-Woo
Lee Dong-Soo
Kim Jin-Man
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Abstract
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Background/Aims: The aim of study was to investigate the expression of TGF-?, TGF-RII and VEGF determined by immunohistochemical analysis with a comparison of the clinicopathological parameters such as tumor size, grade of dysplasia, lymph node metastasis and Dukes’ stage in colorectal adenomas and adenocarcinomas, by use of a tissue microarray method.
Methods: The expression of TGF-?1, TGF-?RII, and VEGF was determined by immunohistochemistry in 20 adenomas and 40 adenocarcinomas. Tissue microarrays consisting of 2 mm cores from corresponding blocks were constructed and stained.
Results: In adenomas, the staining intensity of TGF-?, TGF-?RII and VEGF was increased in a high-grade dysplasia group of patients as compared a with low-grade dysplasia group of patients, respectively. The staining intensity of TGF-?RII was significantly increased in a high-grade dysplasia group of patients than a low-grade dysplasia group of patients (p =0.021). For the adenocarcinomas, the expression and staining intensity of TGF-?1, TGF-?RII and VEGF were increased as compared with the adenomas (p＜0.001). However, no significant correlation was observed between the staining intensity of TGF-?, TGF-?RII and VEGF and the clinicopathological parameters.
Conclusions: The increased expression of TGF-?1, TGF-?RII and VEGF in colorectal adenocarcinoma suggests a role for these proteins in colorectal carcinogenesis. Loss of the growth-inhibitory effect of TGF-? may commence in the early stage of colorectal carcinogenesis. (Korean J Gastrointest Endosc 2007;35:313-320)
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KEYWORD
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TGF-?1, TGF-? receptors, VEGF, Colorectal adenoma, Colorectal adenocarcinoma
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